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posted August 13, 2009 at 10:58 am
One Step At A Time
posted April 28, 2011 at 3:29 pm
Sigh….If one part is missing, the system DOES NOT FALL APART and it is not an immediately lethal condition.
I submit the genetic disease Hemophilia. Hemophilia (lack of factor 8 or 9) is well documented in history and medicine. It is, by itself, not a leathal disease.
In addition, almost every factor has been described as missing in various disease states. I personally have met people lacking foctors 7,8,9, proteins C and S along with people with von Willebrants disease (missing or dysfunctional factor XIII).
These factors are proteins that act as enzymes, or catalysts (for the more chemically minded) that speed up reactions immensely. Fibrinogen will spontaneously convert to fibrin ( it is energetically favorable), but will do so much more slowly than in the presence of thrombin.
As mentioned these diseases are not lethal, but they, for the most part, do shorten an individuals lifespan. Therefore, having a completely functioning cascade therefore provides _an evolutionary advantage_.
This also strikes down the argument that this is too complex to be evolutionarily derived. Rather this is a finely tuned, layered approach to a problem. One can see how the layers were added in a sequential fashion with each mutation providing a better balance of pro and anti-coagulant effects and thus making each organism more successful than their counterpart who lacked that extra step.
See http://en.wikipedia.org/wiki/Coagulation for some more information